Inspired by dramatic discoveries from the Jansky VLA, VLBA, and ALMA, a large collecting area radio interferometer that will open new discovery space from proto-planetary disks to distant galaxies is being designed by the U.S. National Radio Astronomy Observatory (NRAO) and the broad scientific and technical communities. The next-generation VLA (ngVLA), which was strongly endorsed by the Astro2020 Decadal Survey as an essential research facility whose construction should begin this decade, is envisaged as an interferometric array with ten times greater sensitivity and spatial resolution than the current VLA and ALMA, operating in the frequency range of 1.2 - 116 GHz. Replacing both the VLA and VLBA, the ngVLA will be optimized for observations in the spectral region between the superb performance of ALMA at mm and sub-mm wavelengths, and the future Phase I Square Kilometer Array (SKA-1) at decimeter-scale and longer wavelengths. As such, the ngVLA will uniquely tackle a broad range of outstanding scientific questions in modern astronomy by simultaneously delivering the capability to: unveil the formation of Solar System analogues on terrestrial scales; probe the initial conditions for planetary systems and life with astrochemistry; characterize the assembly, structure, and evolution of galaxies from the first billion years to the present; use pulsars in the Galactic center as fundamental tests of gravity; and understand the formation and evolution of stellar and supermassive blackholes in the era of multi-messenger astronomy. In this presentation, I will provide a project update and discuss the overall science case that led to the current technical design of the ngVLA.